Title: Atypical mycobacterial spondylitis in HIV-negative patients identified by 16S rDNA genotyping
Authors: Danaviah S, Govender S, Gordon ML, Cassol S. .
Journal: J Bone Joint Surg Br.,89(3) :346-348 (2007)
Non-tuberculous mycobacterial infections pose a significant diagnostic and therapeutic challenge. We report two cases of such infection of the spine in HIV-negative patients who presented with deformity and neurological deficit. The histopathological features in both specimens were diagnostic of tuberculosis. The isolates were identified as Mycobacterium intracellulare and M. fortuitum by genotyping (MicroSeq 16S rDNA Full Gene assay) and as M. tuberculosis and a mycobacterium other than tuberculosis, respectively, by culture. There is a growing need for molecular diagnostic tools that can differentiate accurately between M. tuberculosis and atypical mycobacteria, especially in regions of the developing world which are experiencing an increase in non-tuberculous mycobacterial infections.
Citation: Danaviah S, Govender S, Gordon ML, Cassol S. . Atypical mycobacterial spondylitis in HIV-negative patients identified by 16S rDNA genotyping J Bone Joint Surg Br.,89(3) :346-348 (2007).
KRISP has been created by the coordinated effort of the University of KwaZulu-Natal (UKZN), the Technology Innovation Agency (TIA) and the South African Medical Research Countil (SAMRC).
Location: K-RITH Tower Building
Nelson R Mandela School of Medicine, UKZN
719 Umbilo Road, Durban, South Africa.
Director: Prof. Tulio de Oliveira