Publication

Title: Dengue Fever Surveillance in Mato Grosso do Sul: Insights from Genomic Analysis and Implications for Public Health Strategies
Authors: Castilho de Arruda L, Giovanetti M, Fonseca V, Zardin M, Lichs G, Asato S, Esposito A, Tokeshi Müller M, Xavier J, Fritsch H, Lima M, de Oliveira C, Santos E, Maziero L, Frias D, Ahad das Neves D, Ferreira da Silva L, Rodrigues Barretos E, Tsuha Oshiro P, Modafari Goday B, Lemos dos Santos J, Kashima S, Albuquerque C, Said R, Rosewell A, Demarchi L, Croda J, Alcantara L, Cavalheiro Maymone Gonçalves C.
Journal: Viruses,15(9):1790. doi: 10.3390/v15091790.: (2023)

Abstract

Since its discovery in early 1916, dengue fever, a common vector-borne illness in Brazil, has resulted in extensive urban outbreaks and poses a serious threat to the public’s health. Understanding the dynamics of Dengue Virus (DENV) serotypes circulating in different regions of Brazil is essential for implementing effective disease control and prevention measures. In response to this urgent need, we conducted an on-site training program in genomic surveillance in collaboration with the Central Laboratory of Health and the Secretary of Health of the Mato Grosso do Sul state. This initiative resulted in the generation of 177 DENV genome sequences collected between May 2021 and May 2022, a period during which over 11,391 dengue fever cases were reported in the state. Through this approach, we were able to identify the co-circulation of two different dengue serotypes (DENV1 and DENV2) as well as the existence of diverse viral lineages within each genotype, suggesting that multiple introduction events of different viral strains occurred in the region. By integrating epidemiological data, our findings unveiled temporal fluctuations in the relative abundance of different serotypes throughout various epidemic seasons, highlighting the complex and changing dynamics of DENV transmission throughout time. These findings demonstrate the value of ongoing surveillance activities in tracking viral transmission patterns, monitoring viral evolution, and informing public health actions.

Download: Full text paper

Citation: Castilho de Arruda L, Giovanetti M, Fonseca V, Zardin M, Lichs G, Asato S, Esposito A, Tokeshi Müller M, Xavier J, Fritsch H, Lima M, de Oliveira C, Santos E, Maziero L, Frias D, Ahad das Neves D, Ferreira da Silva L, Rodrigues Barretos E, Tsuha Oshiro P, Modafari Goday B, Lemos dos Santos J, Kashima S, Albuquerque C, Said R, Rosewell A, Demarchi L, Croda J, Alcantara L, Cavalheiro Maymone Gonçalves C. Dengue Fever Surveillance in Mato Grosso do Sul: Insights from Genomic Analysis and Implications for Public Health Strategies Viruses,15(9):1790. doi: 10.3390/v15091790.: (2023).


KRISP has been created by the coordinated effort of the University of KwaZulu-Natal (UKZN), the Technology Innovation Agency (TIA) and the South African Medical Research Countil (SAMRC).


Location: K-RITH Tower Building
Nelson R Mandela School of Medicine, UKZN
719 Umbilo Road, Durban, South Africa.
Director: Prof. Tulio de Oliveira