Publication

Title: Genomics-based timely detection of dengue virus type I genotypes I and V in Uruguay
Authors: Morel N, Giovanetti M, Fonseca V, Burgueño A, Lima M, Castro E, Guimarães N, Iani F, Bormida V, Cortinas M, Ramas V, Coppola L, Bento A, Rosewell A, Franco L, Mendez Rico J, Lourenço J, Junior Alcantara L, Chiparelli H.
Journal: Heliyon,10(22):e39246. doi: 10.1016/j.heliyon.2024.e39246.: (2024)

Abstract

This study details a genomics-based approach for the early detection of mosquito-borne pathogens, marked by Uruguay's first ever complete genomic sequencing of Dengue Virus type I genotypes I and V. This pioneering effort has facilitated the prompt identification of these genotypes within the country, enabling Uruguayan public health authorities to develop timely and effective response strategies. Further integrated into this approach is a climate-driven suitability measure, closely associated with Dengue case reports and indicative of the local climate's role in the virus's transmission in the country within the changing climate context. The detection of multiple DENV-1 genotypes co-circulating in Uruguay underscores the necessity for proactive surveillance, particularly at borders, to prevent the introduction and dissemination of novel viral strains within the country and the region. This approach aids in facilitating prompt public health responses and intervention strategies, which are crucial in mitigating the impact of dengue outbreaks.

Download: Full text paper

Citation: Morel N, Giovanetti M, Fonseca V, Burgueño A, Lima M, Castro E, Guimarães N, Iani F, Bormida V, Cortinas M, Ramas V, Coppola L, Bento A, Rosewell A, Franco L, Mendez Rico J, Lourenço J, Junior Alcantara L, Chiparelli H. Genomics-based timely detection of dengue virus type I genotypes I and V in Uruguay Heliyon,10(22):e39246. doi: 10.1016/j.heliyon.2024.e39246.: (2024).


KRISP has been created by the coordinated effort of the University of KwaZulu-Natal (UKZN), the Technology Innovation Agency (TIA) and the South African Medical Research Countil (SAMRC).


Location: K-RITH Tower Building
Nelson R Mandela School of Medicine, UKZN
719 Umbilo Road, Durban, South Africa.
Director: Prof. Tulio de Oliveira