KRISP Project: MHC HLA expression levels and HIV-1

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MHC HLA expression levels and HIV-1

KRISP leader

Veron Ransuram

Short title

HLA expression

KRISP expertises

Genetics, Genomics, Population Genetics, Genome-wide association studies, HLA expression, DNA sequencing, Virology, Immunology

Project summary

This is a collaborative project with the National Institute of Health (PI: Mary Carrington). The objective of this project is to determine how HLA variation and expression impact on HIV-1 transmission and disease progression.

Webpage

Funder

National Instiute of Health (NIH)

Publications

Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1. Martin MP, Naranbhai V, Shea PR, Qi Y, Ramsuran V, Vince N, Gao X, Thomas R, Brumme ZL, Carlson JM, Wolinsky SM, Goedert JJ, Walker BD, Segal FP, Deeks SG, Haas DW, Migueles SA, Connors M, Michael N, Fellay J, Gostick E, Llewellyn-Lacey S, Price DA, Lafont BA, Pymm P, Saunders PM, Widjaja J, Wong SC, Vivian JP, Rossjohn J, Brooks AG, Carrington M, J Clin Invest. (2018), pii: 98463. doi: 10.1172/JCI98463:.