We have been invited to give a keynote speech in the International Virus Bioinformatics Meeting (IVBM) 2020, Bern, Switzerland. IVBM 2020 is jointly organized by the European Virus Bioinformatics Center, the University of Bern and the Swiss Institute of Bioinformatics.
This month, we focus on the art & science output of KRISP. This month we published many manuscripts including a key papers with CAPRISA that show a significant decline in HIV incidence in young women in KZN. We also participated in a large study that track HIV incidence in 10 African countries. We have also published a manuscript on the Ethics of HIV-1 molecular research and phylogenetics and worked with Brazilian collaborators to track the dissemination of viruses outbreaks in Brazil.
UKZN African Health Flagship Talks by Dr. Richard Lessells (KRISP UKZN & CAPRISA), Can we stop worrying about HIV drug resistance with the roll-out of dolutegravir? Tuesday, 26 Nov 2019 (11:00am - 12:00), K-RITH building, Nelson R Mandela School of Medicine, UKZN, Durban, South Africa. All welcome!
UKZN African Health Flagship and KRISP Talks by Dr. Benjamin Chimukangara (Phd Graduation Talk, Post-Fellow at KRISP, UKZN) - Increasing levels of HIV pretreatment drug resistance in South Africa. Tuesday, 19 Nov 2019 (11:00am - 12:00), K-RITH building, Nelson R Mandela School of Medicine, UKZN, Durban, South Africa. All welcome!
The SAMRC, through its Strategic Health Innovation Partnership (SHIP) programme, is seeking to fund five highly collaborative projects in the areas of pharmacogenomics with reference to failure of treatments with drugs (or drug classes) for Non-Communicable diseases, specifically Hypertension, Cardiovascular, Diabetes and Cancer in (South) Africa. Total Budget ZAR 12-14 million, which genomics data generation should be done in a DIPLOMICS laboratory, such as KRISP, in South Africa.
KRISP is a competence centre in bioinformatics and computational biology. The group employs skilled personnel that provides infrastructure, support and technological R&D for life sciences and clinical research.
KRISP is giving a keynote speech at the X-Meeting. The X-Meeting is a Brazilian event with international reach which has an average of 300 participants. The Conference is an opportunity for students, researchers and companies to interact and diffuse knowledge.
The X-metting 2019 starts with a special session of Women in Bioinformatics. KRISP is >60% women and it is very exciting to participate in this section. We will cover the tweets to highlight how women can drive in this exciting field.
KRISP and DIPLOMCIS Talks by Prof. Tulio de Oliveira (KRISP, UKZN) - Pharmacogenomics in Precision Medicine RFA by SAMRC with DIPLOMICS: 15 million rands of funding available! Monday, 28 Oct 2019 (11:00am - 12:00), K-RITH building, Nelson R Mandela School of Medicine, UKZN, Durban, South Africa. All welcome and Talk can be remotely attended: https://zoom.us/j/360942224
KRISP has partnered with a great photographer (Samora Chapman) to highlight the human and biodiversity life in South Africa. The photographic exhibition was curated by Tulio de Oliveira and highlight many of the genomics aspects that make us so similar and interesting at genotypic and phenotypic level.
Trends in HIV Prevention, Treatment, and Incidence in a Hyperendemic Area of KwaZulu-Natal, South Africa
Kharsany ABM, Cawood C, Lewis L, Yende-Zuma N, Khanyile D, Puren A, Madurai S, Baxter C, George G, Govender K, Beckett S, Samsunder N, Toledo C, Ayalew KA, Diallo K, Glenshaw M, Herman-Roloff A, Wilkinson E, de Oliveira T, Abdool Karim SS, Abdool Karim Q, JAMA Network Open (2019), 2(11):e1914378. doi:10.1001/jamanetworkopen.2019.14378:.
Yellow fever virus re-emergence and spread in Southeast Brazil, 2016-2019.
Giovanetti M, Lima de Mendonça MC, Fonseca V, Mares-Guia MA, Fabri A, Xavier J, Goes de Jesus J, Gräf T, Damasceno Dos Santos Rodrigues C, Cardoso Dos Santos C, Alves Sampaio S, Lowen Levy Chalhoub F, Bruycker Nogueira F, Theze J, Pecego Martins Romano A, Garkauskas Ramos D, Luiz de Abreu A, Kleber Oliveira W, do Carmo Said RF, Campelo de Alburque CF, de Oliveira T, Fernandes CA, Ferreira Aguiar S, Chieppe A, Carvalho Sequeira P, Rodrigues Faria N, Venâncio Cunha R, Alcantara LCJ, Bispo de Filippis AM., Journal of Virology (2019), JVI.01623-19. doi: 10.1128/JVI.01623-19:.
Recent levels and trends in HIV incidence rates among adolescent girls and young women in ten high-prevalence African countries: a systematic review and meta-analysis.
Birdthistle I, Tanton C, Tomita A, de Graaf K, Schaffnit SB, Tanser F, Slaymaker E, Lancet Global Health (2019), 7: e1521–40:.
Ethical issues associated with HIV molecular epidemiology: a qualitative exploratory study using inductive analytic approaches.
Mutenherwa F, Wassenaar DR, de Oliveira T, BMC Medical Ethics (2019), 20:67, https://doi.org/10.1186/s12910-019-0403-9:.
Mosquito-Borne Viral Diseases: Control and Prevention in the Genomics Era.
Fonseca V, Xavier J, James SE, de Oliveira T, de Filippis AMB, Alcantara LCJ, Giovanetti M, Current Topics in the Epidemiology of Vector-Borne (2019), DOI: 10.5772/intechopen.88769:.
Investigating Triorthogonal Chemoselectivity. Effect of Azide Substitution on the Triazine Core..
Sharma A, Sheyi R, Kumar A, El-Faham A, de la Torre BG, Albericio F., Org Lett. (2019), doi: 10.1021/acs.orglett.9b02878:.
The Role of Adverse Childhood Experiences on Perinatal Substance Use Behaviour in KwaZulu-Natal Province, South Africa..
Bhengu BS, Tomita A, Mashaphu S, Paruk S, AIDS Behav. (2019), doi: 10.1007/s10461-019-02661-y:.
KRISP Public Engagement Photography Exhibition Lifeblood: A Showcase of African Diversity by Samora Chapman
By: Paul and Tulio de Oliveira
Phylogenetic tool to identify the HIV-1 subtypes and recombinants. Query sequences are analysed for recombination using bootscanning methods. The version 3 contains new CRFs (CRF01_AE to CRF47_BF).
A new version of the phylogenetic bootstrap in which the presence of inferred branches in replications is measured using a gradual 'transfer' distance rather than the binary presence or absence index used in Felsenstein's original version. The resulting supports are higher and do not induce falsely supported branches.
This tool is designed to use phylogenetic methods in order to identify the HIV-1 subtype of a specific sequence. The sequence is analysed for recombination using bootscanning methods. The version 3 contains new CRFs (CRF01_AE to CRF47_BF).
This is the first version of the Zika typing tool, which uses phylogenetic analysis to identify the species and genotype of the virus.
This is the first version of our Arbovirus typing tool for Chikungunya, Dengue, Yellow Fever and Zika
This is the first version of the Chikungunya typing tool, which uses phylogenetic analysis to identify the species and genotype of the virus.